Why Patriots cover:  Trying to remain undefeated. Tom Brady and Randy Moss can set individual league records. Giants could rest some players for their wild-card playoff game. New York has not won a home game since October.

Why Giants cover: Will want to spoil Patriots’ perfect season. New England could rest players once the game is in hand. The Patriots have only covered twice in their last seven games.

Total (46 ½): Over is 4-1 in Patriots’ last five road games and 4-1 in Giants’ last five home games.

Buffalo at Philadelphia (-9)

Why Bills cover:  Have rushed for over 100 yards in four straight games averaging 137.3 yards during that span. Brian Dawkins is questionable with a foot injury.

Why Eagles cover:  Donovan McNabb has rushed for 101 yards in his last three games after totaling only 135 in his first 10. That suggests he is finally recovered from the knee injury suffered last season. Bills will be without left tackle Jason Peters, who has been lost for the season with a groin injury.

Total (38): Under is 4-1 in Bills’ last five road games and 6-1-2 in Eagles’ last nine versus a team with a losing record.

Carolina at Tampa Bay (+3)

Why Panthers Cover: Panthers are 9-4 ATS in their last 13 meetings, winning seven of nine and four straight at Tampa. Tampa Bay’s starters are only expected to see limited action. Carolina is 2-0 ATS since Matt Moore took over as the starting quarterback.

Why Buccaneers cover: Backup QB Luke McCown has played well in limited action, completing 65.8 percent of his passes with an 87.4 quarterback rating. Underdog is 8-1 ATS in last nine series meetings.

Total (36): Under is 10-4 in the last 14 meetings.

Cincinnati at Miami (+3)

Why Bengals cover:  Dolphins, allowing 30.5 points per game over their last four, are missing key defensive players Channing Crowder and Zach Thomas.  Miami is on 1-6 ATS at home.

Why Dolphins cover:  Both coaches and players will be hoping to impress Bill Parcells, the team’s new executive VP of football operations. Cincinnati has not won back-to-back games this season and is 0-6 all-time at Miami.

Total (45): Under is 5-0 in Bengals’ last five games.

Detroit at Green Bay (-4)

Why Lions cover:  Packers will likely be without deep threat Greg Jennings and could rest their starters to get ready for the playoffs. With backup QB Aaron Rodgers hurting, Green Bay could use third-stringer Craig Nall to spell Brett Favre. Nall has not attempted a pass this season.

Why Packers cover: Ryan Grant has rushed for 839 yards and seven TDs in nine games since becoming the Packers’ featured back. Detroit has lost 15 straight meetings in Green Bay and is 4-10-1 ATS during that span. Home team is 15-5-1 ATS in last 21 series meetings. Lions will be without starting running back Kevin Jones, who is lost for the season with a knee injury.

Total (39): Under is 4-0 in the last four meetings in Green Bay.

Jacksonville at Houston (-6 ½)

Why Jaguars cover: Fred Taylor has rushed for over 100 yards in five consecutive games. QB Quinn Gray was 2-1 filling in for David Garrard while playing each game on the road. Underdog is 5-1 ATS in last six series meetings.

Why Texans cover: Sage Rosenfels is 3-1 as the starting quarterback. Jaguars are 3-8 ATS in their last 11 meetings and 1-4 ATS in their last five meetings in Houston. Jacksonville can’t improve their playoff position and could rest their starters.

Total (41):  Under is 6-2 in the last eight meetings.

Seattle at Atlanta (-1)

Why Seahawks cover: Mike Holmgren said he might not rest his players. Defense can set a team record for fewest points allowed in a season if it can hold the Falcons under 13. Underdog is 4-1 ATS in last five series meetings. Road team is 4-1 ATS in last five meetings.

Why Falcons cover:  Chris Redman has thrown for 818 yards and six TDs in four games since becoming the starting QB. Atlanta has covered only three times this season, but two of those were at home.

Total (38): Over is 6-0 in Falcons’ last 6 games.

San Francisco at Cleveland (-10)

Why 49ers cover:  With wins against Tampa Bay and Cincinnati, San Francisco is 2-0 both straight up and ATS since Shaun Hill became the staring quarterback. Frank Gore has stepped up his play in the second half. He is averaging 123.3 total yards per game, compared to 80 yards per game in his first seven contests.

Why Browns cover: Have won six straight at home, covering each time.  Niners QB Hill will be playing with a sore back.

Total: (40 ½): Under is 5-0 in Browns’ last five games.

New Orleans at Chicago (+1)

Why Saints cover: Saints are 5-2-1 ATS in their last eight meetings. Need to win to keep playoff hopes alive. Could have Reggie Bush back from a knee injury.

Why Bears cover: Are 2-0 ATS with Kyle Orton as the starting quarterback. Have won last two meetings. Already weak Saints secondary will be without Mike McKenzie, out for the season with a torn ACL.

Total (40): Over is 4-1 in the last five meetings.

Minnesota at Denver (+3)

Why Vikings cover:  Need to win to keep playoff hopes alive. Have won two straight meetings and five of the last seven against Denver. Broncos are giving up 140.7 yards per game on the ground.

Why Broncos cover:  Vikings QB Tarvaris Jackson has been picked off five times in his last two games and will face Champ Bailey and Dre’ Bly in Denver’s secondary. Adrian Peterson has only totaled 108 yards rushing over his last three games.

Total (42): Over is 11-1 in Broncos’ last 12 home games.

San Diego at Oakland (+9)

Why Chargers cover: Are 8-1 ATS in their last nine meetings and 5-0 ATS in their last five meetings in Oakland. A win will give San Diego the third seed in the playoffs. Favorite is 7-1 ATS in last eight series meetings. JaMarcus Russell (24.6 rating) will make his first career start at quarterback. Warren Sapp could was suspended for bumping an official.

Why Raiders cover:  Are 7-3 ATS in their last 10 vs. AFC West. LaDainian Tomlinson has a sore hamstring and could be rested as the Chargers prepare for the playoffs.

Total (42 ½): Under is 6-0 in the last six meetings.

St. Louis at Arizona (-6)

Why Rams cover:  Have won four of their last five meetings at Arizona. Road team is 5-0 SU and 4-1 ATS. Underdog is 8-0 ATS in last eight series meetings.

Why Cardinals cover: Are averaging 24.7 points per game at home. Trying to avoid finishing with a losing record for the first time since 1998. The Rams have allowed the most points (390) in the NFC.

Total (48 ½): Under is 4-1 in the last five meetings in Arizona.

Kansas City at N.Y. Jets (-6 ½)

Why Chiefs cover:  Herm Edwards will be facing his former team for the first time. Jets QB Kellen Clemens is battling rib and shoulder injuries. New York is only averaging 11.3 points per game over its last three games, all losses.

Why Jets cover:  Larry Johnson will not play for the Chiefs. Chad Pennington (86.2 rating) will start at quarterback if Clemens (59.0) can’t go.

Total (34):  Under is 4-1 in Jets’ last five home games and 5-1 in their last six overall.

Pittsburgh at Baltimore (+3)

Why Steelers cover:  Ravens have lost nine consecutive games. Need to win for a chance at the third seed in the AFC playoffs. Baltimore will start third-string QB Troy Smith again. Willis McGahee has broken ribs and is unlikely to play this week.

Why Ravens cover: Ben Roethlisberger is unlikely to play because of an ankle injury. Home team is 5-2 ATS in last seven series meetings. Willie Parker suffered a broken leg last week and is out for the season. Steelers are 1-4 ATS in their last five meetings.

Total (34 ½):  Over is 9-4 in the last 13 meetings.

Dallas at Washington (-9)

Why Cowboys cover: Are 7-2 ATS in their last nine meetings in Washington. Underdog is 17-4 ATS in last 21 series meetings. Coach Wade Phillips said he wants to win for "the integrity of the game." The Cowboys can set a franchise record for most wins in a season with a victory. Terry Glenn is expected to return from knee surgery.

Why Redskins cover: Will clinch a playoff birth with a victory. Todd Collins has thrown four TDs with no interceptions and has a QB rating of 107.0 since replacing the injured Jason Campbell. Cowboys are 1-4 ATS in their last five meetings. Terrell Owens (sprained ankle) probably won’t play and Tony Romo (sore thumb) is expected to be limited.

Total (39 ½): Over is 5-1 in Vikings’ last six home games.

Tennessee at Indianapolis (+6)

Why Titans cover:  Can earn a playoff birth with a win. Titans are averaging 134.1 yards per game on the ground. Colts will play backup QB Jim Sorgi for at least half of the game and will likely rest many of their regulars.

Why Colts cover:  Have won four straight meetings at home, outscoring Tennessee 133-47. Marvin Harrison might see his first action since Week 6.